Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease
نویسندگان
چکیده
منابع مشابه
Nonalcoholic Fatty Liver Disease Treatment
Nonalcoholic fatty liver disease (NAFLD) is increasing in pediatric age group parallel to the growing prevalence of obesity and overweight all around the world. So changing in life style and interventions on obesogenic environment is cornerstone of NAFLD therapy in obese children. Some experts recommend that children and adolescents be encouraged to follow a low-fat, low-glycemic-index diet t...
متن کاملMolecular mechanisms of steatosis in nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is the most important cause of chronic liver disease and is considered the hepatic manifestation of the metabolic syndrome associated with diabetes mellitus type 2. The prevalence of NAFLD in the general population reaches 15-20%. It is also estimated that nonalcoholic steatohepatitis (NASH) affects 3% of the population. NAFLD refers to a wide spectrum o...
متن کاملNonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the peripheral tissues in humans, and could cause severe metabolic disorders by inducing accumulation of lipid in the liver, resulting in the progression of non-alcoholic fatty liver disease (NAFLD)...
متن کاملNonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is known to be associated with an increased risk of colorectal cancer (CRC). However, the relationship between NAFLD and the prognosis of CRC remains unclear. The primary objective of this study was to evaluate the overall survival (OS) and disease-free survival (DFS) rates in patients with CRC and the secondary objective was to compare clinicopathologic...
متن کاملNonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (or NAFLD) is a recently recognized chron ic liver disease, strongly linked to obesity. As the number of obese Americans has doubled in the past three decades, not sur prisingly, NAFLD is becoming increasingly common. The hallmark of persons with NAFLD is having too much fat in the liver. This fat is deposited within the cells of the liver (the medical term is...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Seminars in Liver Disease
سال: 2008
ISSN: 0272-8087,1098-8971
DOI: 10.1055/s-0028-1091980